DOES ETOMIDATE CAUSE HAEMOLYSIS?
نویسندگان
چکیده
منابع مشابه
Haemolysis after etomidate: comparison of propylene glycol and lipid formulations.
We sought to determine if the solvent in the formulation of etomidate is responsible for haemolysis in patients. In a randomized, prospective, double-blind study of 49 patients undergoing otolaryngological surgery, patients received etomidate dissolved in propylene glycol or in lipid emulsion. Concentrations of free haemoglobin and haptoglobin were measured before and for up to 360 min after in...
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OBJECTIVE To evaluate signs of haemolysis in babies of Rh-D negative mothers who underwent prophylaxis with anti-D immunoglobulin during pregnancy. DESIGN The following were evaluated in all babies of Rh-D negative mothers born within a three month period in our department: haemoglobin level, packed cell volume, mean corpuscular volume, reticulocytes, bilirubin level, and direct Coombs' test ...
متن کاملAcute severe intravascular haemolysis: an unrecognised cause of pancreatitis
study showed a significant reduction in lower oesophageal sphincter pressure after intramuscular administration of emepronium bromide. In the nine patients who completed the study no significant change in sphincter pressure was found after four weeks' treatment with a standard oral dose of emepronium bromide. This may have been due to the much lower serum concentrations seen after oral medicati...
متن کاملSolvent for etomidate may cause pain and adverse effects.
We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release. Nine of 10 volunteers who received etomidate in a propylene glycol formulation reported moderate to severe pain on injection; only one of 10 subjects who received a lipid emulsion formulation reported mild pa...
متن کاملA Root Cause Analysis of Haemolysis Encountered in Leuco-filtration of Stored Packed Red Cells Units
Background and Aims: Leukoreduction of blood components has reduced the incidence of transfusion-associated adverse events. Leucofiltration is the most effective method of leukoreduction. We encountered haemolysis in a series of leucofiltered units. This stressed our precious inventory, added to financial loss, increased our turn-around time to issue leucofiltered blood units, and placed doubts...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1993
ISSN: 0007-0912
DOI: 10.1093/bja/70.4.490-b